ANTICORPS SPECIFIQUES DIRIGES CONTRE L'ALPHA-ENOLASE ET METHODE D'UTILISATION DANS DES MALADIES IMMUNITAIRES

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专利权人:

NATIONAL HEALTH RESEARCH INSTITUTES;DCB-USA LLC;DEVELOPMENT CENTER FOR BIOTECHNOLOGY

发明人:

TSAI, SHIH-CHONG,CHANG, MINGL,YUAN, TA-TUNG,TSENG, SHIH-CHI,CHEN, SHYI-JOU,CHIA, WEI-TSO,WANG, HSIN-YUN,LIU, KO-JIUNN,SHIH, NENG-YAO,CHEN, LI-TZONG

申请号：

CA2949064

公开号：

CA2949064A1

申请日:

2014.12.22

申请国别(地区):

CA

年份:

2015

代理人:

摘要：

A method for treating an inflammatory disease or an immune disorder includes administering to a subject in need of such treatment an antagonist against ENO1. The antagonist binds ENO1 and inhibits ENO1 plasminogen receptor activity. The antagonist may be an anti-human ENO1 antibody, or an scFv, Fab, or F(ab)2 fragment thereof, that specifically binds to human ENO1 (GenBank: AAH50642.1) for the treatment of an inflammatory disease or an immune disorder, which may be multiple sclerosis, rheumatoid arthritis, Crohn's disease, ulcerative colitis, systemic Lupus erythematosus, chronic obstructive pulmonary disease (COPD), asthma, allergy, psoriasis, type 1 diabetes mellitus, artherosclerosis or osteoporosis.

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