Johan Zuidema;Theodorus Adrianus Cornelius Flipsen;Rob Steendam;Christine Hiemstra
发明人:
Rob Steendam,Theodorus Adrianus Cornelius Flipsen,Christine Hiemstra,Johan Zuidema
申请号：
US13808492
公开号：
US20130209568A1
申请日:
2011.07.08
申请国别(地区):
US
年份:
2013
代理人:
摘要：
The invention is directed to biodegradable, thermoplastic, phase separated segmented multi-block copolymers. The copolymers of the present invention find use in various biomedical applications as well as in pharmaceutical applications. Provided is a composition for the controlled release of at least one biologically active polypeptide to a host, comprising the at least one biologically active polypeptide encapsulated in a matrix comprising at least one phase separated, thermoplastic multi-block copolymer, the copolymer being characterized in that (i) it comprises at least two hydrolysable segments chosen from prepolymer (A) and prepolymer (B), prepolymer (A) having a Tg lower than 37° C. and prepolymer (B) having a Tm of 40° C.-100° C. under physiological conditions； (ii) the segments being linked by a multifunctional chain-extender； (iii) the segments are randomly distributed over the polymer chain； and (iv) prepolymer (A) contains a segment that is derived from a water soluble polymer.
