BUTTERWORTH SAM,FINLAY MAURICE R. V.,WARD RICHARD ANDREW,KADAMBAR VASANTHA KRISHNA,CHINTAKUNTLA CHANDRASHEKAR REDDY,MURUGAN ANDIAPPAN,REDFEARN HEATHER MARIE
申请号：
ARP120102716
公开号：
AR087336A1
申请日:
2012.07.26
申请国别(地区):
AR
年份:
2014
代理人:
摘要：
Useful in the Treatment or prevention of a disease or medical condition mediated by certain mutated forms of epidermal growth factor receptor (e.g. Activating Mutant L858R Mutant, the Activating of the deletion Mutant and the exon19 Resistance t790m).Such compounds and salts thereof can be useful in the Treatment or prevention of a number of different cancers.Pharmaceutical compositions comprising such compounds and salts thereof, especially useful polymorphic forms of these compounds and salts, to Intermediates useful in the manufacture of such Compounds, and Methods of treatment of diseases mediated by different ways Efore EGFR using such compounds and salts thereof.Claim 1: a compound of formula (1) wherein: G is selected tetrahidropirazolo 4,5,6,7 - [1,5-a] pyridin - 3 - ILO, ILO 1h indole - 3 - 1 - methyl - 1H indole - 3 - ILO and pyrazolo [1,5-a] pyridin - 3 - ilo； r1 is selected from Hydrogen, Fluorine, Chlorine, and methyl cyano； R2 is selected from methoxy and Methyl； and R3 is selected (3R) - 3 - (dimethylamino) - pyrrolidin-3-yl 1 - ilo(3S) - 3 - (dimethyl amino) - pyrrolidin-3-yl yl - 1, 3 - (dimethylamino) - 1 - azetidin ILO [2 - (dimethylamino) ethyl (methyl) amino] - [2 - (methylamino) ethyl (methyl) amino] - 5 - methyl - 2.5 diazaespiro [3.4] oct thiocyanatoacetate (3aR, 6aR) - 5 - metilhexa Hydro - pyrrolo [3,4-b] pyrrole (2H) - ILO - 1, 1 - methyl - 4 - 1,2,3,6 tetrahidropiridin - ILO, ILO metilpiperizin - 4 - 1 -, 4 - [2 - (dimethylamino) - piperazin 2-oxoethyl] ILO - 1 - Methyl - [2 - (4 - metilpiperazin - 1 - il) ethyl] amino -, methyl - [2 - (morpholin-4-yl) ethyl] amino - 1 - amino - 1,2,3,6 tetrahidropiridin - ILO and 4 - 4 - [(2S) - 2 - aminopropanoil piperazin] - 1 - I, or a pharmaceutically acceptable Salt thereof.Útiles en el tratamiento o prevención de una enfermedad o afección médica mediada por ciertas formas mutadas de receptor del factor de crecimiento epidérmico (por ejemplo el mutante activante L858R, el mutante activante de la sup
