BIBEROVIC, VESNA,GRONDARD, LUC,MOURIER, PIERRE,VISKOV, CHRISTIAN
申请号：
EP03807882.0
公开号：
EP1556414B1
申请日:
2003.10.08
申请国别(地区):
EP
年份:
2012
代理人:
摘要：
New mixtures (A) of heparin-derived sulfated polysaccharides have average molecular weight 1500-3000, anti-Xa activity 120-200 IU/mg, anti-IIa activity 0-10 IU/mg and ratio of anti-Xa to anti-IIa activity more than 30； comprise 2-26 saccharide units； have a 4,5- unsaturated uronic acid 2-O-sulfate unit at one terminal； contain a specific hexasaccharide moiety designated DELTAIIa-IIs-Is hexasaccharide； and are in alkali(ne earth) metal salt form. New mixtures (A) of sulfated polysaccharides have the general structure of the constitutive polysaccharides of heparin, an average molecular weight of 1500-3000, an anti-Xa activity of 120-200 IU/mg, an anti-IIa activity of 0-10 IU/mg and a ratio of anti-Xa to anti-IIa activity of more than 30. The constitutive oligosaccharides of (A) comprise 2-26 saccharide units； have a 4,5- unsaturated uronic acid 2-O-sulfate unit at one terminal； contain a hexasaccharide moiety of formula (I) (designated DELTAIIa-IIs-Is hexasaccharide) and are in alkali(ne earth) metal salt form. An Independent claim is included for the preparation of (A).La présente invention concerne des mélanges de polysaccharides dérivés d'héparine ayant un poids moléculaire moyen de 1500 à 3000 Dalton et un rapport Anti-Xa/Anti-IIa supérieur à 30, leur procédé de préparation et les compositions pharmaceutiques les contenant.
