Methods and compositions for increasing alpha-iduronidase activity in the CNS

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专利权人:

Inc.;ArmaGen Technologies

发明人:

Pardridge, William M.,Boado, Ruben J.

申请号：

AU2008282496

公开号：

AU2008282496B2

申请日:

2008.07.25

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

Provided herein are methods and compositions for treating a subject sufferingfrom a deficiency in α-L-Iduronidase in the CNS. The methods include systemicadministration of a bifunctional fusion antibody comprising an antibody toa human insulin receptor and an α-L-Iduronidase. A therapeutically effectivesystemic dose is based on the specific CNS uptake characteristics of human insulinreceptor antibody-α-L-Iduronidase fusion antibodies as describedherein.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/