COMPOSES PRESENTANT UNE ACTIVITE DE TYPE AGONISTE SELECTIVE AU NIVEAU DES RECEPTEURS ADRENERGIQUES ALPHA 2B OU 2B/2C, ET METHODE DE TRAITEMENT FAISANT APPEL A CES COMPOSES
CHOW, KEN,GIL, DANIEL W.,BURKE, JAMES A.,HARCOURT, DALE A.,GARST, MICHAEL E.,WHEELER, LARRY A.,MUNK, STEPHEN A.,GOMEZ, DARIO G.
申请号：
CA2441410
公开号：
CA2441410C
申请日:
2002.03.13
申请国别(地区):
CA
年份:
2012
代理人:
摘要：
A compound having a structure selected from the group consisting of: in whicheach x is independently (1) or (2)； Y is selected from the group consisting ofO；S；N；-(C(R7)z)s-where each R7 IS independently as previously defined fir R1,each z is independently 1-2, and s is 1-3；CH=； -CH=CH ；or Y1CH2_where Y1 is O,N, or S； and the dotted lines are optional double bonds, with the pviso thatif the ring including Y is a cyclohexane ring or a heterocyclic 5 member ringsaid ring is not fully unsaturated, and that if Y is O,N or S, the ringincluding Y contains at least one said double bond, said compound furtherhaving selective agonist activity at the .alpha.2B or .alpha.2B/.alpha.2Cadrenergic receptor subtype(s) over the .alpha.2A adrenergic receptor subtype,and all pharmacologically acceptable salts, esters, stereoisomers and racemicmixtures thereof.
