Union Molecule that binds specifically to inteleuquina 6 (IL - 6)； Pharmaceutical composition that comprises； Nucleic Acid； vector； host Cell； and use for treating disease or Disorder associated with il-6.
BLANCHETOT CHRISTOPHE,DE HAARD JOHANNES,DREIER TORSTEN,DE JONGE NATALIE,VAN DER WONING SEBASTIAN PAUL,ONGENAE NICOLAS
申请号：
CL2014003167
公开号：
CL2014003167A1
申请日:
2014.11.21
申请国别(地区):
CL
年份:
2015
代理人:
摘要：
The present invention provides binding molecules (e.g., antibodies or antigen binding fragments thereof) that specifically bind to and inhibit the biological activity of IL-6 (e.g., human, mouse and non-human primate IL-6). In a preferred embodiment, the antibodies or antigen binding fragments of the invention bind to IL-6 and inhibit its binding to an IL-6 receptor. Such antibodies or antigen binding fragments are particularly useful for treating IL-6-associated diseases or disorders (e.g., inflammatory disease and cancer).La presente invención proporciona anticuerpos o fragmentos de unión del mismo que se unen específicamente e inhiben la actividad biológica de IL-6. El anticuerpo o fragmento de unión del mismo se unen a IL-6 impidiendo la unión de este a su receptor IL-6R, siendo útil para el tratamiento de enfermedades o trastornos asociados a IL-6 como enfermedades inflamatorias y cáncer.
