Jean Luc PERFETTINI,Eric DEUTSCH,Catherine BRENNER,Jean-Christophe CINTRAT,Frederic TARAN
申请号：
US16479415
公开号：
US20190358239A1
申请日:
2018.01.23
申请国别(地区):
US
年份:
2019
代理人:
摘要：
The present invention is drawn to the use of the compounds highlighted in Tables 1 &； 2 and analogs thereof, for enhancing IR-mediated cellular cannibalism in cancer cells. Said compounds are herein called “enhancers of IR-mediated cellular cannibalism”. They can be used to enhance tumor immunogenicity and/or to induce a significant protective anticancer immune response in subjects that will receive or that have received a radiotherapy treatment. In other words, said compounds can be used to potentiate a radiotherapy treatment in a subject in need thereof. Said compounds are preferably chosen in the group consisting of: Mebhydroline 1,5-napthalene disulfonate salt, Flurbiprofen, Minaprine dihydrochloride, Myricetin, Digoxin, Digitoxin, Lanatoside, LOPA87, VP331, RN-1-026, SG6163F, VP450, and VP43.
