Provided herein are pharmaceutical compositions that comprise myrcene,optionally in admixture with cannabinoids andother terpenes, typically substantially free of THC and THCA, for targetingTRPV1 receptors. Also provided are methods of using thepharmaceutical compositions to desensitize TRPV1 receptors in order to treatpain, cardiovascular diseases such as cardiac hypertrophy,overactive bladder, and chronic cough.