The present invention relates to piperidine derivatives, preparation method and medical use thereof. Specifically, the present invention relates to piperidine derivatives of general formula (I), its preparation method and the pharmaceutical composition containing the same, as well as using such estrogen receptor modulators, for treating diseases or conditions that are mediated or dependent upon estrogen receptors, wherein the diseases preferably breast cancer. wherein the substitutes of general formula (I) is defined as the specification.本發明涉及哌啶類衍生物、其製備方法及其在醫藥上的應用。特別地，本發明涉及通式(I)所示的哌啶類衍生物、其製備方法及含有該衍生物的藥物組成物，以及其作為雌激素受體調節劑治療雌激素受體介導的或依賴性的疾病或病症的用途，該疾病特別佳係乳腺癌。其中通式(I)的各取代基同說明書中的定義相同。
