PROCEDE POUR LA PREPARATION DE COMPOSES UTILES EN TANT QU'INHIBITEURS DE TRANSPORTEUR DU GLUCOSE DEPENDANT DU SODIUM

• 收藏
• 分享

专利权人:

MITSUBISHI TANABE PHARMA CORPORATION;JANSSEN PHARMACEUTICA N.V.

发明人:

ABDEL-MAGID, AHMED F.,CHISHOLM, MAUREEN,MEHRMAN, STEVEN,SCOTT, LORRAINE,WELLS, KENNETH M.,ZHANG-PLASKET, FAN,NOMURA, SUMIHIRO,HONGU, MITSUYA,KOGA, YUICHI

申请号：

CA2699285

公开号：

CA2699285C

申请日:

2008.09.09

申请国别(地区):

CA

年份:

2016

代理人:

摘要：

The present invention includes a process for the preparation of compounds offormula (I) havinginhibitory activity against sodium-dependent glucose transporter (SGLT). Theprocess includesa one-step coupling of a compound of formula (V) with a compound of formula(VI-S) in thepresence of an alkyl lithium, which may be selected from(trimethylsilyl)methyl lithium,2,4,6-trimethylphenyl lithium and (triethylsilyl)methyl lithium.(see formula I)(see formula V) (see formula VI-S)

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/