A syringe is provided including an orientation independent indicia that can be used to validate and determine information about the syringe, injection parameters, and/or fluid contained therein. The syringe includes a syringe barrel and an indicia located on a portion of the syringe containing or associated with identifying information about the syringe, one or more injection parameters of a fluid injector, or a fluid filled in the syringe barrel. The indicia is readable by a reader independent of an orientation of the syringe relative to the reader. A fluid injection system for providing fluid into a patient is also provided. The injection system includes the syringe having an orientation-independent indicia, an injector having at least one syringe receiving port for receiving the syringe, and a controller. The controller can be configured to obtain information from the indicia and provide instructions for performing injections to the injector, based on the information.
