The present invention relates in a first aspect to a nitric oxide donor for use in the treatment of chronic fatigue syndrome also known as myalgic encyphalomyelitis. In particular, the present invention relates to the use of a pharmaceutical composition containing a nitric oxide donor for the treatment of chronic fatigue syndrome/myalgic encyphalomyelitis in a subject afflicted with said disease.In a further aspect, the present invention relates to a combination of a nitric oxide donor with a B-cell depleting agent for use in the treatment of chronic fatigue syndrome. Said combination may be provided in form of a kit comprising pharmaceutically effective dosages of said compounds. Further, the present invention relates to a method for treating chronic fatigue syndrome comprising the step of administering nitric oxide donor to a subject afflicted therewith.
