WYNNE, GRAHAM MICHAEL,WREN, STEPHEN PAUL,JOHNSON, PETER DAVID,PRICE, PAUL DAMIEN,DE MOOR, OLIVIER,NUGENT, GARY,STORER, RICHARD,PYE, RICHARD JOSEPH,DORGAN, COLIN RICHARD
申请号：
CA2641880
公开号：
CA2641880C
申请日:
2007.02.09
申请国别(地区):
CA
年份:
2014
代理人:
摘要：
There are disclosed compound of Formula (1): A1, A2, A3 and A4 which may bethe same or different, represent N or CR1, X is a divalent group selected fromO, S(O)n, C=W, NR4, NC(=O)R5 and CR6R7, W is O, S, NR20, Y is N or CR8, one ofR4, R5, R6, R8, R9 and NR20 represents - L -R3, in which L is a single bond ora linker group, additionally, R1, R3 - R9, which may be the same or different,independently represent hydrogen or a substituent and R20 represents hydrogen,hydroxyl, alkyl optionally substituted by aryl, alkoxy optionally substitutedby aryl, aryl, CN, optionally substituted alkoxy, optionally substitutedaryloxy, optionally substitute alkanoyl, optionally substituted aroyl, NO2,NR30R31, in which R30 and R31, which may be the same or different, representhydrogen, optionally substituted alkyl or optionally substituted aryl；additionally, one of R30 and R31 may represent optionally substituted alkanoylor optionally substituted aroyl, n represents an integer from 0 to 2, inaddition, when an adjacent pair of A1 - A4 each represent CR1, then theadjacent carbon atoms, together with their substituents may form a ring B,when X is CR6R7, R6 and R7, together with the carbon atom to which they areattached may form a ring C, or a pharmaceutically acceptable salt thereof, inthe manufacture of a medicament for the therapeutic and/or prophylactictreatment of Duchenne muscular dystrophy, Becker muscular dystrophy orcachexia.
