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TREATMENT OF STROKE USING ISOLATED PLACENTAL CELLS
专利权人:
ANTHROGENESIS CORPORATION
发明人:
ZEITLIN, ANDY,PAL, AJAI
申请号:
NZ59129409
公开号:
NZ591294A
申请日:
2009.08.20
申请国别(地区):
NZ
年份:
2012
代理人:
摘要:
Disclosed is the use of a therapeutically effective amount of isolated human placental stem cells in the manufacture of a composition for treating an individual having a disease or disorder characterized by a disruption in the flow of blood in or around the brain, wherein the isolated human placental cells are: CD10+, CD34-, and CD105+; CD200+ and HLA-G+; CD73+, CD105+, and CD200+; CD200+ and OCT-4+; CD73+, CD105+ and HLA-G+; CD73+ and CD105+ and facilitate the formation of one or more embryoid-like bodies in a population of placental cells comprising said stem cell when said population is cultured under conditions that allow the formation of an embryoid like body; or OCT-4+ and facilitate the formation of one or more embryoid-like bodies in a population of placental cells comprising the stem cell when said population is cultured under conditions that allow formation of embryoid-like bodies; or any combination thereof. Further disclosed is the use of an effective amount of isolated human placental stem cells in the manufacture of a composition for treating an individual having a disease or disorder characterized by a disruption in the flow of blood in or around the brain, wherein said cells express one or more genes at a detectably higher level than a bone marrow-derived mesenchymal stem cell, wherein said one or more genes are one or more of ACTG2, ADARBI, AMIG02, ARTS-I, B4GALT6, BCHE, Cilorf9, CD200, COL4AI, COL4A2, CPA4, DMD, DSC3, DSG2, ELOVL2, F2RL1, FLJI0781, GATA6, GPRI26, GPRCSB, ICAM1, IER3, IGFBP7, ILIA, IL6, IL18, KRTI8, KRT8, LIPG, LRAP, MATN2, MEST, NFE2L3, NUAKI, PCDH7, PDLIM3, PKP2, RTN1, SERPINB9, ST3GAL6, ST6GALNACS, SLCI2A8, TCF21, TGFB2, VTN, and ZC3HI2A, and wherein said bone marrow-derived stem cell has undergone a number of passages in culture that is equivalent to the number of passages said placental stem cell has undergone.
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中国工程科技知识中心
来源网址:
http://www.ckcest.cn/home/

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