CHEN, CHING-SHIH,陈 庆士,陳 慶士,LIN, YI LING,林宜玲,林宜玲,JADHAV, APPASO,贾达夫 艾帕索,賈達夫 艾帕索
申请号：
TW106125899
公开号：
TW201806596A
申请日:
2017.08.01
申请国别(地区):
TW
年份:
2018
代理人:
摘要：
Described herein are substituted phenyl-heteroaryl-aryl compounds, and corresponding methods, pharmaceutical compositions, and kits directed to antiviral therapy. The antiviral activity of the compounds is tolerant of a wide diversity of viral serotypes and species, being effective against Zika virus Japanese encephalitis virus dengue virus strains: DENV1 Hawaii, DENV2 PL046, DENV3 H087, and DENV4 H241 and influenza H1N1. Further, the antiviral activity of the compounds may be independent on the type of infected host cell. Accordingly, the antiviral activity of the described compounds, methods, pharmaceutical compositions, and kits may be generally applicable to a wide range of human and animal viral pathogens.本文描述針對抗病毒療法的經取代之苯基-雜芳基-芳基化合物、及相應的方法、醫藥組成物及套組。該等化合物之抗病毒活性可用於多種多樣的病毒血清型及物種,對茲卡病毒;日本腦炎病毒;以下登革熱病毒品系:DENV1夏威夷、DENV2 PL046、DENV3 H087及DENV4 H241;及流感病毒H1N1係有效的。此外,該等化合物之抗病毒活性可不依賴於經感染宿主細胞之類型。因此,所述化合物、方法、醫藥組成物及套組之抗病毒活性通常可適用於廣範圍的人類及動物病毒病原體。(無)
