Disclosed is the use of FBP aldolase in the preparation of a drug activating AMPK. Also disclosed are the uses of FBP aldolase in the preparation of a drug for inhibiting cholesterol synthesis, a drug for reducing fatty acid synthesis, a drug for preventing and/or treating diabetes, a drug for preventing and/or treating tumours, a drug for preventing and/or treating Parkinsons disease, a drug for preventing and/or treating Alzheimers disease, or a drug for prolonging the lifespan of an organism. The use of FBP aldolase as a target to develop drugs to activate AMPK overcomes the difficulties of directly using AMPK as a drug target in the prior art and has good application prospects.本發明屬於生物醫藥領域,涉及FBP aldolase在製備啟動AMPK的藥物中的用途。本發明還涉及在製備抑制膽固醇合成的藥物、降低脂肪酸合成的藥物、預防及/或治療糖尿病的藥物、預防及/或治療腫瘤的藥物、預防及/或治療帕金森氏症的藥物、預防及/或治療阿茲海默症的藥物或者延長有機體壽命的藥物中的用途。本發明實現了可以將FBP aldolase作為靶點來開發藥物用來啟動AMPK,克服了先前技術中直接以AMPK為藥物靶點而存在的困難,具有良好的應用前景。
