EISAI R&D MANAGEMENT CO., LTD.;PRESIDENT AND FELLOWS OF HARVARD COLLEGE
发明人:
KISHI, Yoshito,KIRA, Kazunobu,ITO, Ken
申请号：
SG11201908603P
公开号：
SG11201908603PA
申请日:
2018.04.03
申请国别(地区):
SG
年份:
2019
代理人:
摘要：
30 10 20 Days 0 -4 , -control -411FHali-B 0.05 mg/kg -•<；. Compound (1) 0.2 mg/kg Re la t ive tumor volum e 4 • 3 - 2 GO N Go O C (12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT) CORRECTED VERSION (19) World Intellectual Property Organization International Bureau (43) International Publication Date 1111111111110110101011111011010 I 1011111101110110141011110# (10) International Publication Number WO 2018/187331 A8 11 October 2018 (11.10.2018) WIPO I PCT (51) International Patent Classification: CO7D 493/22 (2006.01) A61K 31/357 (2006.01) A61P 35/00 (2006.01) (21) International Application Number: PCT/US2018/025887 (22) International Filing Date: 03 April 2018 (03.04.2018) (25) Filing Language: English (26) Publication Language: English (30) Priority Data: 62/482,030 05 April 2017 (05.04.2017) US 62/526,677 29 June 2017 (29.06.2017) US 15/814,105 15 November 2017 (15.11.2017) US 62/586,416 15 November 2017 (15.11.2017) US (71) Applicants: PRESIDENT AND FELLOWS OF HAR- VARD COLLEGE [US/US]； 17 Quincy Street, Cam- bridge, MA 02138 (US). EISAI R&D MANAGEMENT CO., LTD. [JP/JP]； 4-6-10 Koishikawa, Bunkyo-ku, Tokyo, 112-8088 (JP). (72) Inventors: KISHI, Yoshito； 75 Cambridge Parkway, Unit E902, Cambridge, MA 02142-1233 (US). KIRA, Kazunobu； C/o Eisai Co., Ltd., Tsukuba Research Labora- tories, 5-1-3 Tokodai, Ibaraki, Tsukuba-shi, 300-2635 (JP). ITO, Ken； C/o Eisai Co., Ltd., Tsukuba Research Labora- tories, 5-1-3 Tokodai, Ibaraki, Tsukuba-shi, 300-2635 (JP). (74) Agent: BAKER, C., Hunter； Wolf, Greenfield & Sacks, P.C., 600 Atlantic Avenue, Boston, MA 02210-2206 (US). (81) Designated States (unless otherwise indicated, for every kind of national protection available): AE, AG, AL, AM, AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN, HR, HU, ID, IL, IN, IR, IS, JO, JP, KE, KG, KH, KN, KP, KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD,
