Brian Seed;Chia-Iun Tsai;Glen S. Cho;Jia Liu Wolfe
发明人:
Brian Seed,Jia Liu Wolfe,Glen S. Cho,Chia-Iun Tsai
申请号：
US12374616
公开号：
US08993295B2
申请日:
2007.07.20
申请国别(地区):
US
年份:
2015
代理人:
摘要：
The present invention provides methods and compositions for treating various diseases through selective killing of targeted cells using a combinatorial targeting approach. The invention features protoxin fusion proteins containing a cell targeting moiety and, a modifiable activation moiety which is activated by an activation moiety not naturally operably found in, on, or in the vicinity of a target cell. These methods also include the combinatorial use of two or more therapeutic agents, at minimum comprising a protoxin and a protoxin activator, to target and destroy a specific cell population.
