СОМОЗА, Вероника (DE),ХОФМАНН, Томас (DE),ЛАНЦ, Инго (DE),ШТИБИЦ, Герберт (DE),БИТОФ, Герхард (DE),ЛАНГ, Роман (DE),РУБАЧ, Мальте (DE)
申请号：
RU2011150412/10
公开号：
RU2011150412A
申请日:
2010.06.15
申请国别(地区):
RU
年份:
2013
代理人:
摘要：
1. A method of producing an extract of trigonellin-containing organic material enriched with N-methylpyridinium (NMP), comprising the steps of: (a) trigonellin-containing organic material being dewaxed； (b) trigonellin-containing organic material is fried； (c) fried trigonellin is processed -containing organic material with hot water to obtain an aqueous extract； and (d) add NMP to the aqueous extract. 2. The method according to claim 1, wherein the degree of frying trigonellin-containing organic material after frying in Stage (b) is at least 50 divisions of the scale. The method according to claim 1 or 2, wherein in Step (d) at least 2.95 mg NMP / 100 ml are added to the aqueous extract. The method according to any one of claims 1 to 3, in which the final NMP-enriched extract contains at least 23 mg / l NMP. The method according to any one of claims 1 to 4, in which the ratio of NMP / N-alkanoyl-5-hydroxytryptamide (C5HT) × 100 in the final NMP-rich extract is at least 100.6. The method according to any one of claims 1 to 5, wherein the trigonellin-containing organic material is selected from the group consisting of coffee, in particular Coffea arabica, Coffea canephora, Coffea spp. And Psilanthus spp., Members of Fabaceae, in particular Pisum sativum, Glycine max, Phaseolus vulgaris, Lens culinaris, Cicer arietinum and Trigonella foenum graecum, members of Chenopodiaceae, in particular Chenopodium quinoa, and members of Poaceae, in particular Avena sativa. 7. A method according to any one of claims 1 to 6, wherein the trigonellin-containing organic material is Coffea arabica, provenience Columbia or Coffea arabica, provenience Brazil. Enriched with N-methylpyridinium (NMP) extract obtained by the method according to any one of claims 1 to 7.9. A pharmaceutical composition containing, in a therapeutically effective amount, enriched with N-methylpyridinium (NMP) ext1. Способ получения обогащенного N-метилпиридинием (NMP) экстракта тригонеллин-содержащего органическо
