PROBLEM TO BE SOLVED: To provide a novel α-substituted propionic acid derivative, and the α-substituted propionic acid derivative which functions as an agonist selective to PPARγ.SOLUTION: The α-substituted propionic acid derivative is expressed by general formula (I) [wherein R1 is adamantyl, phenyl which may have not a substituent or may have a substituent, pyridyl, pyrimidinyl, pyrazinyl, piperidine, azepyl or piperazinyl (substituent is a halogen atom) or the like R2 and R4 are the same or different and are each hydrogen or halogen R3 is straight chain or branched 1-10C alkyl R5 is phenyl which may have a substituent, or cyclohexyl and n is an integer of 0-10].COPYRIGHT: (C)2012,JPO&INPIT【課題】新規α-置換プロピオン酸誘導体及び、該α-置換プロピオン酸誘導体PPARγに選択的なアゴニストとして機能するα-置換プロピオン酸誘導体。【解決手段】下記一般式(I)で表されるα-置換プロピオン酸誘導体。[式中、R1はアダマンチル基、無置換又は置換基を有していても良いフェニル基、ピリジル基、ピリミジニル基、ピラジニル基、ピペリジン基、アゼピル基若しくはピペラジニル基(置換基は、ハロゲン原子)等、R2及びR4は同一又は相異なって水素原子又はハロゲン原子、R3は炭素数1から10の直鎖状又は分岐状アルキル基、R5は置換基を有していても良いフェニル基又はシクロヘキシル基、nは0から10の整数を表す]【選択図】図1
