Oligooxopiperazines for p53 reactivation

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专利权人:

发明人:

Paramjit S. Arora,Quintin Pan,Anna Mapp

申请号：

US14160037

公开号：

US09695153B2

申请日:

2014.01.21

申请国别(地区):

US

年份:

2017

代理人:

摘要：

The present invention relates to oligooxopiperazines for reactivating p53. The oligooxopiperazines comprise two or three oxopiperazine rings and substantially mimic helix αB of the C-terminal transactivation domain of Hypoxia-Inducible Factor 1α. Methods of using the oligooxopiperazines are also disclosed. Exemplary oligooxopiperazines include those of Formula I below (wherein A, R1, R2, R3, R4, and B are as defined herein).

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