Disclosed are compounds which inhibit the activity of anti-apoptotic Bcl-2 proteins, compositions containing the compounds and methods of treating diseases during which is expressed anti-apoptotic Bcl-2 protein.本發明揭示一種抑制抗細胞凋亡Bcl-2蛋白活性之化合物,含有該等化合物之組合物及治療表現抗細胞凋亡Bcl-2蛋白之疾病的方法。