1. A method of increasing the permeability of the cell layer, characterized in that the method includes contact of the cell layer with the surface of the device, where the cell layer contains epithelial cells, the surface contains many nanostructures formed on the surface, the nanostructures are in the form of a predetermined pattern, where after the contact of the cell layer with the surface of the cell layer exhibits increased permeability to the drug compound. 2. The method according to claim 1, characterized in that after the contact of the cell layer with the surface, the transepithelial electrical resistance of the cell layer is less than about 95% of the transepithelial electrical resistance of the layer before contact with the surface of the device. The method according to claim 1, characterized in that after the contact of the cell layer with the surface, the transepithelial electrical resistance of the cell layer is less than about 85% of the transepithelial electrical resistance of the layer before contact with the surface of the device. The method according to claim 1, characterized in that after the contact of the cell layer with the surface, the transepithelial electrical resistance of the cell layer is less than about 70% of the transepithelial electrical resistance of the layer before contact with the surface of the device. The method according to claim 1, characterized in that the pattern further includes microstructures, where the nanostructures have a smaller cross-sectional size than microstructures. The method according to claim 5, characterized in that the device further comprises second nanostructures having a smaller cross-sectional size,1. Способ повышения проницаемости клеточного слоя, отличающийся тем, что способ включает контакт клеточного слоя с поверхностью устройства, где клеточный слой содержит эпителиальные клетки, поверхность содержит множество наноструктур, сформированных на поверхности, наноструктуры располагаются в виде заданного
