William Columbus Ian LAFFERTY;Alan SMITH;Peter James WATTS;Jonathan David CASTILE
发明人:
Peter James WATTS,Jonathan David CASTILE,William Columbus Ian LAFFERTY,Alan SMITH
申请号：
US13541325
公开号：
US20120270903A1
申请日:
2012.07.03
申请国别(地区):
US
年份:
2012
代理人:
摘要：
An intranasnal spray device contains a composition for the intranasal delivery of fentanyl or a pharmaceutically acceptable salt thereof to an animal includes an aqueous solution of fentanyl or a pharmaceutically acceptable salt thereof and a pharmaceutically acceptable additive selected from (i) a pectin and (ii) a poloxamer and chitosan or a salt or derivative thereof； provided that when the composition comprises a pectin it is substantially free of divalent metal ions； and which, in comparison to a simple aqueous solution of fentanyl administered intranasally at the same dose, provides a peak plasma concentration of fentanyl (Cmax) that is from 10 to 80% of that achieved using a simple aqueous solution of fentanyl administered intranasally at an identical fentanyl dose. A method for treating or managing pain by intranasally administering the composition is also disclosed.
