The invention relates to oral, topical or injectable compositions for combating liver fluke parasites in mammals, comprising at least one indole derivative active agent according to a compound of formula (I). The invention also provides for a method for eradicating and controlling liver fluke parasite infections and infestations in a mammal comprising administering the compositions of the invention comprising a compound of formula (I) to the mammal in need thereof. The invention provides an alternative composition for combating liver fluke parasites in mammals, especially as reports of parasitic resistance to currently known active agents, such as triclabendazole, are increasing.
