The invention relates to a cosmetic composition comprising a bio-active system which combines (i) a stable form in aqueous solution of ATP (adenosine-tri-phosphate) with optionally an ATP precursor, e.g. Gp<；SUB>；4<；/SUB>；G (diguanosine tetraphosphate), or Ap<；SUB>；4<；/SUB>；A (diadenosine tetraphosphate), and (ii) at least one biomimetic peptide comprising at most six amino acids, mimicking a cutaneous polypeptide or a cutaneous protein, or a biomolecule which is agonist or antagonist in relation to the aforementioned polypeptide or protein. According to the invention, the composition takes the form of a water-in-oil or oil-in-water emulsion, the bio-active system being included in the aqueous phase.
