The present disclosure pertains to a system configured to amplify the pressure and/or flow rate of a pressurized flow of breathable gas by entraining oxygen gas and/or ambient air with an air amplifier and a venturi valve at or near a blending gas source, distally (e.g., remotely) from an interface appliance of a subject interface (e.g., away from the face of the subject) to reduce noise from the system heard by the subject. The system is configured to provide this pressure support and/or ventilation with oxygen therapy. The system is configured to deliver ventilatory and/or pressure support with oxygen therapy while decreasing output requirements of the blending gas source and/or pressure generator.
