METHOD OF MODIFYING SURFACE OF PANCREATIC ISLETS USING HYPER-BRANCHED PEG AND PANCREATIC ISLETS HAVING MODIFIED SURFACE USING THE METHOD农业专利-农业专业知识服务系统

发明人:: BYUN, YOUNG RO,변영로,AHN, CHEOL HEE,안철희,KIM, JI WOONG,김지웅,JEONG, JEE HEON,정지헌,BYUN, YOUNG ROKR,AHN, CHEOL HEEKR,KIM, JI WOONGKR,JEONG, JEE HEONKR

摘要：: The present invention relates to a method for modifying surface of pancreatic islets using dendritic PEG and surface-modified pancreatic islets using the same. The method for modifying surface of pancreatic islets according to the present invention has no effect on cell viability by coating dendritic PEG on the surface of pancreatic islets and no sensitivity in response to glucose concentration. The pancreatic islets coated by the dendritic PEG can be useful in pre-treatment of the pancreatic islets by effectively decreasing activation of immune cells through extending survival term of pancreatic islets after transplantation.본 발명은 덴드리틱 PEG(dendritic PEG)를 이용한 췌장소도 표면개질 방법 및 이를 이용한 표면개질된 췌장소도에 관한 것으로, 본 발명에 따른 췌장소도의 표면개질 방법은, 덴드리틱 PEG를 췌장소도의 표면에 코팅하여 세포 생존율은 영향이 없고, 당 농도에 반응하는 민감성 영향을 받지 않으며, 효과적으로 면역세포의 활성화를 감소시켜 이식 후 췌장소도의 생존기간을 늘림으로써 상기 덴드리틱 PEG가 코팅된 췌장소도를 췌장소도 이식의 전처리 과정에 유용하게 사용될 수 있다.