Metal Sensitive Mutants of Matrix Metalloproteases and uses thereof

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专利权人:

Ge Wei;Rudolph D. Paladini;H. Michael Shepard

发明人:

Rudolph D. Paladini,Ge Wei,H. Michael Shepard

申请号：

US13999061

公开号：

US20150196625A9

申请日:

2014.01.07

申请国别(地区):

US

年份:

2015

代理人:

摘要：

Provided herein are methods of using modified matrix metalloprotease (MMP) enzymes that exhibit regulated activity in the presence of calcium. The methods include conditionally controlling the activity of the MMPs through the use of calcium to treat fibrotic diseases or conditions involving a component of the extracellular matrix (ECM).

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中国工程科技知识中心

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