The present invention relates to a novel hepatocyte-like cell progenitor and/ora novel hepatocyte-like cell derived via definitive endoderm from human blastocyst-derivedstem (hBS) cells, to a method for the preparation of such cells and to the potentialuse of such cells in e.g. pharmaceutical drug discovery and development, toxicitytesting, cell therapy and medical treatment. In particular is presented a definitiveendoderm derived hepatocyte-like cell with important liver-expressed markergenes and important metabolizing enzymes, as well as drug transporters.
