Methods for identifying Kawasaki Disease subjects resistant to intravenous immunoglobulin (IVIG) are provided, comprising the step of detecting at least one risk allele of the SNPs disclosed herein or calculating a weighted genetic risk score based on the presence of the risk alleles. Also provided are methods of treating Kawasaki Disease subjects with IVIG resistance, by administering a first dose of IVIG and an adjunctive therapy.本發明提供一種用於識別對靜脈注射免疫球蛋白(IVIG)抗性的川崎氏病個體的方法，其包含檢測本文揭露的SNP的至少一風險對偶基因或基於風險對偶基因的存在計算加權遺傳風險評分的步驟。亦提供一種治療患有IVIG抗性的川崎氏病個體的方法，其藉由施予第一劑IVIG以及輔助性治療。
