Vaccine containing mononuclear cells or undifferentiated myeloid cells loaded with natural killer T cell ligand and antigen

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专利权人:

ソウル ナショナル ユニバーシティー インダストリー ファウンデーション

发明人:

カン チャン－ユイル,コ ヒョン－ジョン,イ ジョン－ミ,キム ヨン－ジョン,カン チャン-ユイル,コ ヒョン-ジョン,イ ジョン-ミ,キム ヨン-ジョン

申请号：

JP2010533949

公开号：

JP5153885B2

申请日:

2007.11.28

申请国别(地区):

JP

年份:

2013

代理人:

摘要：

The present invention relates to an immuno-therapeutic and prophylactic vaccine comprising monocytes or immature myeloid cells (IMCs) loaded with the ligand of natural killer T cell and an antigen for the prevention and treatment of infectious disease or cancer, more precisely, an immuno-therapeutic and prophylactic vaccine comprising monocytes or IMCs loaded with α-galactosylceramide (αGalCer), a kind of glycolipid and a natural killer T cell ligand, and antigen. Monocytes or immature myeloid cells (IMCs) therein, which are easily obtainable, unlike dendritic cells, not only induce a significant level of cytotoxic T lymphocyte responses but also have a prophylactic and therapeutic effect on malignant tumor. Therefore, the immuno-therapeutic and prophylactic vaccine of the present invention can be effectively used as an immunotherapeutic agent.

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中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/