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Compounds with activity and Muscarinic receptor antagonist activity of B2 adrenergic receptor agonist
专利权人:
CHIESI FARMACEUTICI S.P.A.
发明人:
IAN LINNEY,FABIO RANCATI
申请号:
ARP130104529
公开号:
AR093825A1
申请日:
2013.12.05
申请国别(地区):
AR
年份:
2015
代理人:
摘要:
Compounds that act as the opposite of muscle receptors, and mixtures of agonists that act as adrenergic B2 receptors, compounds that contain these components, therapeutic uses, and other pharmaceutical active ingredients. 1. Property 1: compound (1) with general formula property,Q is a set of formulas (2)(3) (4)Z is h or h, chosen from y and y, which are different sets of equations (5) or (6),respectively, where A¹ and A² are independently absent or are C₁₋₆ alkylene;B is absent or selected from the group consisting of arylene and heteroarylene, optionally substituted with one or more groups selected from halogens, C₁₋₆ alkyl,a. Halo Aquilo c83217c831832627 and Alcoy c83218c833126;C is absent or is -OC (O) - or is one of the groups of formula (7) - (9) where R⁴ is H or linear or branched C₁₋₄ alkyl; D is absent or selected from the group consisting of arylene and heteroarylene, optionally substituted with one or more C₁₋₆ alkyl groups;N and N are 0 or 1 to 3 integers independently; E is absent or selected between - o-y-oc (o);G is arileno; R1 and R2 are independent h or arilo; R3 is a set of formulas (10) or (11),R83099 is a formula group (12), where p is 0 or 1, P is absent or Co, q is absent or 1, W is heterogeneous; and salt that can be accepted or dissolved in medicine.Compuestos que actúan como antagonistas de los receptores muscarínicos a la vez que como agonistas del receptor b2 adrenérgico, composiciones que los comprenden, usos terapéuticos y combinaciones con otros ingredientes farmacéuticamente activos. Reivindicación 1: Un compuesto caracterizado porque tiene la fórmula general (1), donde Q es un grupo de fórmula (2), (3) ó (4); Z es H o OH; Y se selecciona entre Y e Y¹ que son grupos divalentes de fórmula (5) ó (6), respectivamente, donde A¹ y A² en forma independiente están ausentes o son alquileno C₁₋₆; B está ausente o se selecciona entre el grupo que consiste en arileno y heteroarileno, opcionalmente sustituido con uno o más grupos seleccionados e
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