Antagonist anti-Notch3 antibodies and their use in the prevention and treatment of Notch3-related diseases

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专利权人:

INC.;GENENTECH

发明人:

Zhou, Bin-Bing Stephen,Fung, Sek Chung,Li, Kang,Li, Yucheng,Singh, Sanjaya

申请号：

AU2007333805

公开号：

AU2007333805B2

申请日:

2007.12.17

申请国别(地区):

AU

年份:

2013

代理人:

摘要：

The present invention relates to antagonist antibodies that specifically bindto Notch 3 and inhibit its activation. The present invention includes antibodiesbinding to a conformational epitope comprising the first Lin12 domain and thesecond dimerization domain. The present invention also includes uses of theseantibodies to treat or prevent Notch 3 related diseases or disorders.

来源网站：

中国工程科技知识中心

来源网址：

http://www.ckcest.cn/home/