ALEXANDER LAURENCE MANDEL,ELYSE MARIE JOSEE BOURQUE,GEOFFREY C. WINTERS,GRAHAM ALBERT EDWIN GARNETT,JAMES R. RICH,STUART DANIEL BARNSCHER,TOM HAN HSIAO HSIEH
申请号：
BR112017005126
公开号：
BR112017005126A2
申请日:
2015.09.17
申请国别(地区):
BR
年份:
2018
代理人:
摘要：
Compounds having cytotoxic and/or anti-mitotic activity are disclosed. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed. Also disclosed are compositions having the structure: (T)-(L)-(D), wherein (T) is a targeting moiety, (L) is an optional linker, and (D) is a compound having cytotoxic and/or anti-mitotic activity.
