Processes of preventing tumor cell mestastases induced by surgical procedures such as resection or biopsy are provided. Some embodiments include applying a tissue adhesive to a structure that is then adhered to tissue providing a tensioning surface for exposing normal tissue for cutting thereby preventing contact of a surgical instrument with tumor tissue. Methods of preventing tumor cell metastasis during or following biopsy are also provided whereby an adhesive alone or optionally along with a structure occupy a track left by a biopsy needle and provide a physical barrier between tumor tissue and normal tissue. The inventive processes improve patient outcome by reducing surgically induced tumor cell metastases.
