Maria Grazia Rimoli,Antonio Calignano,Rosario Cuomo,Gianpiero Boatto,Enrico Abignente,Daniela Melisi,Annalisa Curcio,Elvira Luongo,Giovanna La Rana,Oscar Sasso,Giovanni Sarnelli,Roberto Russo,Maria Ni
申请号：
US13015980
公开号：
US08551958B2
申请日:
2011.01.28
申请国别(地区):
US
年份:
2013
代理人:
摘要：
Pro-drugs of all non-steroidal anti-inflammatories with free acid function derivatized with an ester group, which have the general structural formula given below (I) where A is: aspirin, diflunisal, benorylate, ibufenac, diclofenac, indomethacin, sulindac, ketorolac, ibuprofen, naproxen, ketoprofen, fenoprofen, flurbiprofen, mefenamic acid, meclof enamic acid, flufenamic acid, niflumic acid, and where in the ester group R can be a sugar (amongst which aldose, or ketose pentose, or esose selected from a group of D- and L-enantioiuers of ribose, glucose, galactose, mannose, arabinose, xilose, allose, altrose, gulose, idose and talose and substituted derivatives thereof, such as glucosamine, galactosamine, N-acetyl glucosamine, N-acetyl galactosamine, N-acetyl ribosamine), a disaccharide, a trisaccharide or an oligosaccharide.
