Disclosed are compounds of formula I, pharmaceutically acceptable salts, solvates, hydrates, stereoisomers or tautomers thereof, and methods for their preparation. A specific example of compounds of formula I is (4,6-bis-thiomethyl-2(4-(4-trifluoromethylbenzoyl)amino-benzyl)pyrimidin-5-yl)acetic acid Also disclosed is the use of a compound of formula I for treating an allergic diseases, eosinophil-related diseases and basophil-related diseases asthma such as exercise induced asthma, allergic rhinitis, atopic dermatitis, allergic conjunctivitis, Churg-Strauss syndrome, sinusitis, basophilic leukemia, chronic urticaria, basophilic leukocytosis, psoriasis, eczema, inflammatory bowel disease, ulcerative colitis, Crohns disease, COPD (chronic obstructive pulmonary disorder) and arthritis.
