are described compounds and their salts, drugs, \u043a\u043e\u043d\u044a\u044e\u0433\u0430\u0442\u044b, derivative forms and their applications.in some aspects and options described compounds or their salts, drugs, \u043a\u043e\u043d\u044a\u044e\u0433\u0430\u0442\u044b derived, form active against one or more \u043f\u0440\u043e\u0442\u0435\u0438\u043d\u043a\u0438\u043d\u0430\u0437, including Fms, kit, Flt3, TrkA,TrkB and TrkC.also describes the methods of using them to treat diseases and conditions, including diseases and conditions associated with the activity of one or more of the Fms, kit, Flt3, TrkA, TrkB and TrkC,including rheumatoid arthritis, osteoarthritis, osteoporosis, \u043e\u043a\u043e\u043b\u043e\u043f\u0440\u043e\u0442\u0435\u0437\u043d\u044b\u0439 \u043e\u0441\u0442\u0435\u043e\u043b\u0438\u0437, systemic sclerosis, \u0434\u0435\u043c\u0438\u0435\u043b\u0438\u043d\u0438\u0440\u0443\u044e\u0449\u0438\u0435 disorders, multiple sclerosis, and shark oh marie aces.amyotrophic lateral sclerosis, alzheimers disease, parkinsons disease, total ischemia, ulcerative colitis, crohns disease, immune \u0442\u0440\u043e\u043c\u0431\u043e\u0442\u0438\u0447\u0435\u0441\u043a\u0443\u044e \u043f\u0443\u0440\u043f\u0443\u0440\u0443, \u0430\u0442\u0435\u0440\u043e the ms, systemic lupus.\u043c\u0438\u0435\u043b\u043e\u043f\u043e\u0434\u0433\u043e\u0442\u043e\u0432\u043a\u0443 to \u0430\u0443\u0442\u043e\u0433\u0435\u043d\u043d\u043e\u0439 transplantation, graft rejection, glomerulonephritis, interstitial nephritis, lupus nephritis, tubular necrosis, diabetic \u043d\u0435\u0444\u0440\u043e\u043f\u0430\u0442\u0438\u044e, \u0440\u0435\u043d\u0430\u043b\u044c\u043d\u0443\u044e hypertrophy.diabetes type i, acute pain, inflammatory nature, \u043d\u0435\u0432\u0440\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0443\u044e pain, acute myeloid leukemia, melanoma, multiple myeloma, breast cancer, r ak prostate gland.pancreatic cancer, lung cancer, ovarian cancer, glioma, gl
