AGENTS AGONISTES DE CD47 INDUISANT LA MORT CELLULAIRE PROGRAMMÉE ET LEUR UTILISATION DANS LES TRAITEMENTS DE MALADIES ASSOCIÉES À DES DÉFAUTS DANS LA MORT CELLULAIRE PROGRAMMÉE
Université Pierre et Marie Curie (Paris 6);Centre National de la Recherche Scientifique
发明人:
申请号：
EP16305543.7
公开号：
EP3243522A1
申请日:
2016.05.10
申请国别(地区):
EP
年份:
2017
代理人:
摘要：
The present invention relates to cyclic peptides mimetics of the C-terminal binding domain of TSP-1.The present invention also relates to the use of these cyclic peptides as agonists of CD47 and their ability to trigger programmed cell death (PCD).The present invention further relate to a pharmaceutical composition for use in the treatment of diseases associated with defects in PCD such as cancers and immunological disorders (including chronic inflammation) and comprising at least one cyclic peptide according to the invention.
