BERNAL ANCHUELA, FRANCISCO JAVIER,CARRASCAL RIERA, MARTA,CATURLA JAVALOYES, JUAN FRANCISCO,GRACIA FERRER, JORDI,MATASSA, VICTOR GIULIO,TERRICABRAS BELART, EMMA,TALTAVULL MOLL, JOAN,ERRA SOLA, MONTSERR
申请号：
ES12717685
公开号：
ES2545853T3
申请日:
2012.04.26
申请国别(地区):
ES
年份:
2015
代理人:
摘要：
A compound of formula (I), or a pharmaceutically acceptable salt, or solvate, or N-oxide, or stereoisomer or deuterated derivative thereof: ** Formula ** where, X represents a nitrogen atom or a -CR6 group； n represents 0, 1, 2 or 3； each of Ra and Rb independently represents a hydrogen atom, a C1-C4 haloalkyl group, a C1-C4 hydroxyalkyl group or a C1-C4 linear or branched alkyl group； R1 represents a hydrogen atom, a C1-C4 linear or branched alkyl group, a C1-C4 haloalkyl group, a C3-C10 cycloalkyl group, a C3-C10 cycloalkenyl group, a C6-C14 monocyclic or bicyclic aryl group, a group 5 to 14 membered monocyclic or bicyclic heteroaryl containing at least one heteroatom selected from O, S and N, or a 5 to 14 membered monocyclic or bicyclic heterocyclic group containing at least one heteroatom selected from O, S and N, in wherein the cycloalkyl, cycloalkenyl, aryl, heteroaryl and heterocyclyl groups are unsubstituted or substituted with one or more substituents selected from a halogen atom, a hydroxyl group, a cyano group, a linear or branched C1-C4 alkyl group, a haloalkyl group C1-C4, a C1-C4 hydroxyalkyl group, a C3-C4 cycloalkyl group, a group - (CH2) 1- 3CN, a group - (CH2) 0-3OR8, a group - (CH2) 0-3NR7R8, a group -C (O) - (CH2) 1-3-CN, a group -C (O) - (CH2) 0-3-R8, a group -C (O) - (CH2) 0-3-NR 7R8, a group -S (O) 2 (CH2) 0-3R8, a group -S (O) 2 (CH2) 0-3NR7R8 or a group - (CH2) 0-3 (phenyl) -OR8； each of R2 and R3 independently represents a hydrogen atom, a halogen atom, a hydroxyl group, a cyano group, a C1-C4 alkoxy group, a C1-C4 haloalkyl group, a C1-C4 hydroxyalkyl group, a cycloalkyl group C3-C7, a group -NR'R '', or a linear or branched C1-C6 alkyl group, wherein said alkyl group is unsubstituted or substituted with one or more substituents selected from a C1-C4 alkoxy group, a cyano group or a C3-C7 cycloalkyl group； R4 represents a hydrogen atom, a C1-C4 alkoxy group, a C1-C4 haloalkyl group, a C1-C4 hydroxyalkyl group, a C3-C7 cycloalkyl group, a g
