Topical composition comprising a variant of a natural OB-fold protein, said variant having between 5 and 32 mutated moieties at the interface of the union of said natural OB-fold protein to its natural ligand.Composición tópica que comprende una variante de una proteína natural de pliegue-OB, presentando dicha variante entre 5 y 32 restos mutados en la interfase de la unión de dicha proteína natural de pliegue-OB a su ligando natural.