The Board of Trustees of the Leland Stanford Junior University
发明人:
LIU, Jie,WEISSMAN, Irving L.,MAJETI, Ravindra
申请号：
EP17865245
公开号：
EP3532497A4
申请日:
2017.10.26
申请国别(地区):
EP
年份:
2020
代理人:
摘要：
Polypeptide compositions comprising a human immunoglobulin constant region with a modified IgG4 hinge region having an N-terminal deletion of 1, 2, 3, 4, 5 amino acids, relative to a native human IgG4 hinge sequence are provided. In some embodiments the hinge sequence further comprises the amino acid substitution S228P (Eu numbering). Polypeptides comprising the modified sequence optionally comprise a binding moiety specific for an epitope that is present on red blood cells； and can provide for reduced agglutination of hematopoietic cells compared to a comparable polypeptide with a native hinge region.
