Joan W. Miller,Evangelos S. Gragoudas,Reem Z. Renno
申请号：
US13422462
公开号：
US20120323162A1
申请日:
2012.03.16
申请国别(地区):
US
年份:
2012
代理人:
摘要：
Provided are methods and compositions for the photodynamic therapy (PDT) of ocular conditions characterized by the presence of unwanted choroidal neovasculature, for example, neovascular age-related macular degeneration. The selectivity and sensitivity of the PDT method can be enhanced by combining the PDT with an anti-angiogenesis factor, for example, angiostatin or endostatin, or with an apoptosis-modulating factor. Furthermore, the selectivity and sensitivity of the PDT may be further enhanced by coupling a targeting moiety to the photosensitizer so as to target the photosensitizer to choroidal neovasculature.
