The present invention discloses compounds that can modulate protein kinase activity and are used in the prevention and treatment of protein kinase-related diseases. Specifically, the present invention relates to a benzofuran pyrazolamine protein kinase inhibitor, belonging to a compound that modulates anaplastic lymphoma kinase (ALK) activity, and a method for preparing such a compound and such compound to prevent ALK-related diseases. Alternatively, it can be used for the manufacture of a drug to be treated, and solve the problem of drug resistance of first generation ALK inhibitors, second generation ALK inhibitors. [Selection] Figure 2本発明はプロテインキナーゼ活性の調節可能で、プロテインキナーゼ関連疾患の予防および治療に用いられる化合物を開示する。具体的に、本発明はベンゾフランピラゾールアミン類プロテインキナーゼ阻害薬に関し、未分化リンパ腫キナーゼ(ALK)活性を調節する化合物に属し、このような化合物の調製方法およびこのような化合物をALK関連疾患を予防または治療する薬の製造に用いる用途を提供し、第一世代のALK阻害薬、第二世代のALK阻害薬の薬物耐性の問題を解決することができる。【選択図】図2