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PHARMACEUTICAL COMPOSITIONS FOR DIRECT INTRODUCTION CONTAINING A STEROID HORMONE
专利权人:
ПЬЕР ФАРБ МЕДИКАМЕНТ (FR)
发明人:
ЛЕВЕР Эли (FR),БУГАРЕ Жоэль (FR)
申请号:
RU2010128471/15
公开号:
RU2010128471A
申请日:
2008.12.04
申请国别(地区):
RU
年份:
2012
代理人:
摘要:
1. Pharmaceutical compositions for transdermal administration of a monophasic water-alcohol type with an amount of alcohol of more than 30%, containing a steroid hormone associated with at least one fatty acid and propylene glycol ester as a penetrating agent. ! 2. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they contain N, N-diethyl-m-toluamide, or DEET, as a non-polar solvent in the aqueous-alcohol phase in a concentration of from 0.1 to 0.5 % (mass / mass) of the composition. ! 3. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they are in the form of gels or solutions containing testosterone as a steroid hormone with a concentration of from 0.1% to 5% (weight / weight) of the composition. ! 4. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they contain at least one gelling agent, such as carbomer. ! 5. The pharmaceutical compositions for percutaneous administration according to claim 1, characterized in that the concentration of the fatty acid ester and propylene glycol ranges from 0.5% to 10% (weight / weight) of the composition. ! 6. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they contain 2.5% (w / w) propylene glycol monolaurate. ! 7. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they contain 5% (mass / mass) of propylene glycol monocaprylate. ! 8. The pharmaceutical compositions for transdermal administration according to claim 1, characterized in that they contain a mixture of propylene glycol monolaurate and propylene glycol monocaprylate, preferably in equal weight. ! 9. Pharmaceutical com1. Фармацевтические композиции для чрескожного введения монофазного водно-спиртового типа с количеством спирта более 30%, содержащие стероидный гормон, связанный по мен
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