Devices and methods are provided for adjusting a tissue gap of an end effector of a surgical device. In general, a surgical device can be configured to have an adjustable gap of space between a cartridge jaw and an anvil of the device's end effector when the end effector is in a closed position. The end effector can be configured to removably seat a cartridge therein. The cartridge can be configured to define the gap of space between the cartridge jaw and the anvil when the end effector is in the closed position.
