An ultrasonic surgical instrument includes a housing, a waveguide extending distally from the housing, an end effector coupled to the distal end of the waveguide, an ultrasonic transducer retained within the housing, and a controller. The ultrasonic transducer is coupled to the proximal end of the waveguide and configured to produce mechanical motion for transmission along the waveguide to the end effector. The controller is configured to control an amplitude of the mechanical motion of the ultrasonic transducer in accordance with at least one amplitude value. The at least one amplitude value is adjusted according to an age of the ultrasonic transducer to compensate for aging of the ultrasonic transducer. Methods for controlling the amplitude of the mechanical motion of an ultrasonic transducer to compensate for aging of the ultrasonic transducer are also provided.