A compound having the structure : wherein R<；SUB>；1<；/SUB>；, R<；SUB>；2<；/SUB>；, R<；SUB>；3<；/SUB>；, R<；SUB>；4<；/SUB>；, R<；SUB>；5<；/SUB>；, R<；SUB>；6<；/SUB>；, R<；SUB>；7<；/SUB>； and R<；SUB>；9<；/SUB>； are independently hydrogen, C<；SUB>；1 <；/SUB>；to C<；SUB>；6<；/SUB>； alkyl or substituted alkyl, halogen, sulfate or glucuronide moieties； the ---- symbol represents either a single or a double bond and when the ---- symbol is a double bond and forms a keto group at position 3 or 17, then no R<；SUB>；7<；/SUB>； or R<；SUB>；6 <；/SUB>；is present, respectively； the symbol --- represent the presence or absence of a bond at position 10； and the ~~~ symbol represents any type of bond regardless of the stereochemistry. The invention also embraces the enantiomers, other stereochemical isomers, hydrates, solvates, tautomers and pharmaceutically acceptable salts of said compounds.
